Now showing items 281-300 of 478

    • Development of automated fluorescence microscopy methods to assist the diagnosis and treatment of human malignancies 

      Flaberg, Emilie (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-11-09)
      Fluorescence microscopy is a powerful technique used in many biological laboratories. It is often used as an illustrative tool but in combination with manual efforts, valuable quantitative results can also be obtained. ...
    • Molecular epidemiology of tuberculosis 

      Groenheit, Ramona (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-11-09)
      Tuberculosis is a global epidemic, with one third of the world’s population estimated to be infected, around 9 million new active cases per year and close to 2 million deaths per year. Without adequate chemotherapy ...
    • MHC class I molecules in Natural Killer cell education and tolerance 

      Brodin, Petter (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-11-03)
      The immune system needs to respond to danger but remain tolerant to normal cells and tissues. Natural killer cells achieve tolerance to self by the use of inhibitory receptors recognizing MHC class I molecules on healthy ...
    • Modulation of p53's transcriptional function by small molecules 

      Nikulenkov, Fedor (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-11-01)
      p53 tumour suppressor is a transcriptional factor which induces apoptosis or growth arrest in response to stress thus eliminating damaged cells. p53 function is frequently abrogated in tumours either via inactivation ...
    • Virus Host Interactions in SARS Coronavirus Infection 

      Gunalan, Vithiagaran (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-10-31)
      The global outbreak of Severe Acute Respiratory Syndrome which began in 2002 and ended in 2003 resulted in over 8000 cases in 29 countries, causing an atypical pneumonia which resulted in a case fatality rate of ~10%. ...
    • Antigenic variation and virulence in Plasmodium falciparum malaria: Studies on the surface protein PfEMP1 

      Blomqvist, Karin (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-10-17)
      Approximately 40% of the world’s population is at risk of contracting malaria, a disease caused by the intracellular protozoan Plasmodium. The species Plasmodium falciparum is responsible for the majority of severe ...
    • Impairment of B cell trafficking and differentiation during HIV-1 infection 

      Dang, Vu Phuong Linh (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-10-05)
      During the course of HIV-1 infection, several B cell dysfunctions occur as result of virus replication and indirect mechanisms of immunopathology. The B cells abnormalities include hypergammaglobulinemia, a decreased ...
    • Evaluation of HIV testing strategies and monitoring of immune responses in HIV-vaccinated individuals in Tanzania 

      Aboud, Said (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-09-22)
      This thesis describes studies on the evaluation of human immunodeficiency virus (HIV) enzyme-linked immunosorbent assays (ELISAs) and simple rapid HIV assays for use in HIV testing strategies in resource-limited settings ...
    • Genetic and antigenic diversity in Pneumocystis jirovecii 

      Beser, Jessica (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-08-26)
      Pneumocystis jirovecii is a human specific, atypical fungus with a worldwide distribution that causes disease in immunocompromised individuals. The fungus proliferates in the lungs where it binds to epithelial alveolar ...
    • The impact of vascular structure and function on tumor growth, retinopathy, and antiangiogenic therapy 

      Hedlund, Eva-Maria (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-08-22)
      Tumors produce multiple angiogenic factors to stimulate neovascularization that is essential for tumor growth, invasion and metastasis. Despite the known angiogenic functions of each individual factor, the interplay between ...
    • The zebrafish as a model to elucidate human diseases and development 

      Lee, Samantha Lin Chiou (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-08-15)
      This thesis explores the zebrafish as a model organism to illuminate our understanding of processes that orchestrate the progression of cancer metastasis and myogenesis. First, I describe the successful establishment ...
    • Role of IL-7 in immune activation during HIV-1 infection 

      Sammicheli, Stefano (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-08-02)
      Viral replication, lymphopenia and microbial translocation at the mucosal surfaces lead to a chronic state of immune activation during HIV-1 infection. Chronic immune activation is believed to impact on the functionality ...
    • Exported proteins of the malaria parasite Plasmodium falciparum: characterization of blood-stage antigen 332 

      Nilsson, Sandra (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-07-28)
      Plasmodium falciparum malaria is one of the most important infectious diseases in the world. Following invasion of the human red blood cell (RBC), the P. falciparum parasite dramatically remodels its host cell by ...
    • Molecular characterization of Mycobacterium tuberculosis isolates in Mozambique 

      Viegas, Sofia Omar (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-05-27)
      Tuberculosis (TB) is one of the major health problems in Mozambique. It is estimated that 27,000 deaths caused by TB occur each year with an estimated incidence and prevalence rate of 431 and 504 per 100,000 population ...
    • Staphylococcus aureus alpha-toxin : natural fragments and effects on intestinal epithelial cells 

      Kwak, Young-Keun (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-05-26)
      Staphylococcus aureus is a human pathogen, commonly found in healthy humans as a part of normal flora. alpha-toxin is thought to be largely responsible for the pathogenesis of the bacterium. This cytotoxin has been shown ...
    • Small Molecules as Research Tools for Studying the Biology of the Tumour Suppressor p53 

      Spinnler, Clemens (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-05-24)
      p53 is a potent tumour suppressor that is inactivated in the majority, if not all human cancers. In about 50% of the cases, the gene is mutated and in the rest it is rendered inactive mainly by deregulation of its ...
    • Regulation and role of IL-7 production in HIV-1 infection 

      Pham, Hong Thang (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-05-16)
      The concentration of interleukin-7 (IL-7) in human serum is elevated in various clinical conditions associated with lymphopenia, including HIV-1 infection. IL-7 is an essential factor for T cell differentiation and ...
    • Tissue- and site-specific effects of PPARγ activation and its role in chronic inflammation 

      Pott, Sebastian (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-05-09)
      Developmental programming, metabolism, immune function and tissue homeostasis in multicellular organisms are regulated by a plethora of stimuli. Transcription factors (TFs) convert incoming signals to appropriate ...
    • Exploring the complexity of functional hiv-1 specific t-cell responses and global virus-host genetic variability 

      Pérez, Carina (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2011-02-18)
      HIV has become one of the biggest health problems up to date. After 30 years of tremendous effort, the development of an HIV vaccine is still far from achieved. One of the main issues is the high mutation rate of the virus ...
    • Regulation of biofilm formation in Salmonella typhimurium and Escherichia coli Nissle 1917 

      Monteiro, Cláudia (Inst för mikrobiologi, tumör- och cellbiologi / Dept of Microbiology, Tumor and Cell Biology, 2010-12-20)
      Bacteria have the ability to grow in cell communities designated biofilms. This mode of growth is widespread and offers numerous advantages to the bacteria in terms of survival, persistence and propagation. Bacteria have ...